Publicaciones recientes

Pérez M, Biescas E, De Andrés X, Leginagoikoa I, Salazar E, Berriatua E, Reina R, Bolea R, De Andrés D, Juste RA, Cancer J, Gracia J, Amorena B, Badiola J, Luján L. Visna/maedi virus serology in sheep: Survey, risk factors and implementation of a successful control programme in Aragón (Spain). Vet J. 186(2):221-225. (2010),

Hortells P, Monleón E, Acín C, Vargas A, Vasseur V, Salomon A, Ryffel B, Cesbron I, Badiola JJ, Monzón M. The effect of metal imbalances on scrapie neurodegeneration. Zoonoses and Public Health 57:358-66 (2010).

Lyahyai J, Serrano C, Ranera B, Badiola JJ, Zaragoza P, Martin-Burriel I. Effect of scrapie on the stability of housekeeping genes. Anim Biotechnol.;21 : 1-13. (2010).

Badiola JJ y  Pumarola M. Encefalopatias espongiformes transmisibles. 146 págs. (2010)  ISBN: 978-84-9905-073-7 Editorial: Ediciones Mayo S.A. Barcelona. España.

Bolea R, Hortells P, Martín-Burriel I, Vargas A, Ryffel B, Monzón M, Badiola JJ. Consequences of dietary manganese and copper imbalance on neuronal apoptosis in a murine model of scrapie. Neuropath Appl Neuro 36: 300-311  (2010).

Bolea R, Vidal E, Marín B, Márquez M, Vargas A, Pumarola M, Badiola JJ. Rapid chromatographic immunoassay study of brain PrPsc distribution in classical scrapie. J Vet Diagn Invest 22: 82-85. (2010).

Leginagoikoa I, Minguijón E, Juste R, Barandika J, Amorena B, De Andrés D, Badiola JJ, Luján L, Berriatua E. Effects of housing on the incidence of visna/maedi virus infection in sheep flocks. Res Vet Sci 88: 415-21 (2010).

Salazar E, Monleón E, Bolea R, Acín C, Pérez M, Alvarez N, Leginagoikoa I, Juste R, Minguijón E, Reina R, Glaria I, Berriatua E, De Andrés D, Badiola JJ, Amorena B, Luján L. Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep. Vet Res 41: 58-67 (2010).

González L, Sisó S, Monleón E, Casalone C, Van Keulen LJ, Balkema-Buschmann A, Ortiz-Peláez A, Iulini B, Langeveld JP, Hoffmann C, Badiola JJ, Jeffrey M, Acín C. Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe. J Gen Virol 91:2630-2641 (2010).

Monleón E, Garza M, Sarasa R, Alvarez-Rodriguez J, Bolea R, Monzón M, Vargas MA, Badiola JJ, Acín C. An assessment of the efficiency of PrPsc detection in rectal mucosa and third-eyelid biopsies from animals infected with scrapie. Vet Microbiol 147:237-243 (2011).

Serrano C, Bolea R, Lyahyai J, Filali Hm, Varona L, Marcos-Carcavilla A, Acín C, Calvo JH, Serrano M, Badiola JJ, Zaragoza P, Martín-Burriel I. Changes in HSP gene and protein expression in natural scrapie with brain damage. Vet Res 42:13-24 (2011).

Galindo-Cardiel I, Fernández-Jiménez M, Luján L, Buesa J, Espada J, Fantova E, Blanco J, Segalés J, Badiola JJ. Novel group A rotavirus G8 P[1] as primary cause of an ovine diarrheic syndrome outbreak in weaned lambs. Vet Microbiol 149: 467-471 (2011).

Filali H, Martín-Burriel I, Harders F, Varona L, Lyahyai J, Zaragoza P, Pumarola M, Badiola JJ, Bossers A, Bolea R. Gene expression profiling and association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals. PLoS One. 6(5):e19909. (2011).

Garza MC, Fernández-Borges N, Bolea R, Badiola JJ, Castilla J, Monleón E. In utero vertical transmission of scrapie in natural infected ewes. PLoS One. 6(12): e27525. (2011).

Álvarez-Rodríguez J, Monleón E, Sanz A, Badiola JJ, Joy M. Rumen fermentation and histology in light lambs as affected by forage supply and lactation length. Res Vet Sci. 92: 247-253 (2012). 

Larruskain A, Minguijón E, Arostegui I, Moreno B, Juste RA, Jugo BM. Microsatellites in immune-relevant regions and their associations with Maedi-Visna and ovine pulmonary adenocarcinoma viral diseases. Vet Immunol Immunop 145:438-446. (2012)

Badiola Díez JJ, Acín C, Bolea R, Moreno B, Marín B, Monleón E, Monzón M, Vargas A. Erradicación de la Peste bovina. Erradicación y Control de las Enfermedades Producidas por Virus. Ed. Fundación Ramón Areces. 21 – 45. (2011) ISBN M-16405-2012.

Filali H, Martín-Burriel I, Harders F, Varona L, Serrano C, Acín C, Badiola JJ, Bossers A, Bolea R. Medulla oblongata transcriptome changes during presymptomatic natural scrapie and their association with prion-related lesions. BMC Genomics. 13, 399. (2012).

Toledano A, Álvarez MI, Monleón E, Toledano-Díaz A, Badiola JJ, Monzón M. Changes induced by natural scrapie in the calretinin-immunopositive cells and fibres of the sheep cerebellar cortex. Cerebellum. 11(2):593-604 (2012).

Monzón M, Acín C, Bolea R, Monleón E, Vargas MA, Moreno B, Marín B, Hernández R, Pitarch JL, Hedman C, Jirón W, Filali H, Sarasa R, Garza MC, Badiola JJ. Las enfermedades priónicas, un antes y un después para la seguridad de los alimentos. Aplicaciones de la biotecnología en la ciencia veterinaria. Ed. Instituto Tomás Pascual y Sanz. 135-177.(2012).

Sarasa R, Martínez A, Monleón E, Bolea R, Vargas A, Badiola JJ, Monzón M. Involvement of astrocytes in transmissible spongiform encephalopathies: a confocal microscopy study. Cell Tissue Res 350(1):127-134 (2012).

Moreno B, Collantes-Fernández E, Villa A, Navarro A, Regidor-Cerrillo J, Ortega-Mora LM. Ocurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions. Vet Parasitol. 187:312-318 (2012).

Hedman C, Lyahyai J, Filali H, Marín B, Serrano C, Monleón E, Moreno B, Zaragoza P, Badiola JJ, Martín-Burriel I, Bolea R. Differential gene expression and apoptosis markers in presymptomatic scrapie affected sheep. Vet Microbiol. 159:23-32. (2012).

Larruskain A, Minguijón E, García-Etxebarria K, Arostegui I, Moreno B, Juste RA, Jugo BM. Amino acid signatures in the Ovar-DRB1 peptide-binding pockets are associated with Ovine Pulmonary Adenocarcinoma susceptibility/resistence. Biochem Bioph Res Co 428:463-468 (2012).

Lyahyai J, Mediano DR, Ranera B, Sanz A, Remacha AR, Bolea R, Zaragoza P, Rodellar C, Martín-Burriel I. Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood. BMC Vet Res. 8(1):169. (2012).

Minguijón E, González L, De Las Heras M, Gómez N, García-Goti M, Juste RA, Moreno B. Pathological and aetiological studies in sheep exhibiting extra-thoracic metástasis of ovine pulmonary adenocarcinoma (Jaagsiekte). J Com Path. Epub:1-9. (2012).

Aporta A, Arbues A, Aguilo JI, Monzon M, Badiola JJ, de Martino A, Ferrer N, Marinova D, Anel A, Martin C, Pardo J. Attenuated Mycobacterium tuberculosis SO2 vaccine candidate is unable to induce cell death. PLoS One. 7(9): e45213. (2012).

Garcia-Ispierto I, López-Helguera I, Tutusaus J, Serrano B, Monleón E, Badiola J, López-Gatius F. Coxiella burnetii shedding during the peripartum period and subsequent fertility in dairy cattle. Reprod Domest Anim 48(3):441-446. (2013).

de Andrés X, Ramírez H, Bertolotti L, San Román B, Glaria I, Crespo H, Jáuregui P, Minguijón E, Juste R, Leginagoikoa I, Pérez M, Luján L, Badiola JJ, Polledo L, García-Marín JF, Riezu JI, Borrás-Cuesta F, de Andrés D, Rosati S, Reina R, Amorena B. An insight into a combination of ELISA strategies to diagnose small ruminant lentivirus infections. Vet Immunol Immunopathol 152: 277-288 (2013).

Filali H, Vidal E, Bolea R, Márquez M, Marco P, Vargas A, Pumarola M, Martin-Burriel I, Badiola JJ. Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep. Vet Res 44:14 (2013).

Acín C, Martín-Burriel I, Monleón E, Lyahyai J, Pitarch JL, Serrano C, Monzón  M, Zaragoza P, Badiola JJ. Prion protein gene variability in spanish goats. Inference through susceptibility to classical scrapie strains and pathogenic distribution of peripheral PrP(sc.). PLoS One. 8(4):e61118. (2013).

Aguilo JI, Alonso H, Uranga S, Marinova D, Arbués A, de Martino A, Anel A, Monzon M, Badiola J, Pardo J, Brosch R, Martin C. ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis. Cell Microbiol 2013 Jul 15. doi: 10.1111/cmi.12169.

Pérez M, Muñoz JA, Biescas E, Salazar E, Bolea R, de Andrés D, Amorena B, Badiola JJ, Reina R, Luján L. Successful Visna/maedi control in a highly infected ovine dairy flock using serologic segregation and management strategies. Prev Vet Med 112: 423-7 (2013).

Sarasa R, Becher D, Badiola JJ, Monzón M. A comparative study of modified confirmatory techniques and additional immuno-based methods for non-conclusive autolytic Bovine spongiform encephalopathy cases. BMC Vet Res. 18: 212 (2013).

Filali H, Martín-Burriel I, Harders F, Varona L, Hedman C, Mediano DR, Monzón M, Bossers A, Badiola JJ, Bolea R. Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie. BMC Genomics Jan 23;15:59. doi: 10.1186/1471-2164-15-59. (2014).

Tutusaus J, López-Gatius F, Serrano B, Monleón E, Badiola JJ, Garcia-Ispierto I.Serological and shedding patterns after Coxiella burnetii vaccination in the third gestation trimester in dairy cows. Acta Vet Hung. 62:145-54 (2014).

Garza MC, Monzon M, Marin B, Badiola JJ, Monleón E. Distribution of peripheral PrPsc in sheep with naturally acquired Scrapie. PLoS One. 2014 May 14:9 (5):e97768. doi: 10.1371/journal.pone.0097768. (2014).

Solans L, Uranga S, Aguilo N, Arnal C, Gomez AB, Monzon M, Badiola J, Gicquel B, Martin C. Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice. Vaccine 32:5192-5197(2014).

Hernández RS, Sarasa R, Toledano A, Badiola JJ, Monzón M. Morphological approach to assess the involvement of astrocytes in prion propagation. Cell Tissue Res. Tissue Res 358: 57-63  (2014).

González L, Pitarch JL, Martin S, Thurston L, Moore J, Acín C, Jeffrey M. Identical pathogenesis and neuropathological phenotype of Scrapie in Valine, Arginine, Glutamine/Valine, Arginine, Glutamine sheep infected experimentally by the oral and conjunctival routes. J Comp Pathol 150: 47-56 (2014).

González L, Pitarch JL, Martin S, Thurston L, Simmons, C. Acín C, Jeffrey M. Influence of the Prnp genotype on the pathogenesis and neuropathological phenotype of sheep Scrapie after oral infection J Comp Pathol 150: 57-70 (2014).

Salazar E, Berriatua E, Pérez M, Marín B, Acín C, Martín-Burriel I, Reina R,  de Andrés D,  Amorena B, Badiola JJ, Luján L. Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers. Span J Agric Res 12: 676-682 (2014).

Pérez M, Biescas E, Reina R, Glaria I, Marín B, Marquina A, Salazar E, Alvarez N, de Andrés D, Fantova E, Badiola JJ, Amorena B, Luján L. Small ruminant lentivirus-induced arthritis: Clinicopathologic findings in sheep infected by a highly replicative SRLV B2 genotype. Vet Pathol 52 1:132-139 (2015).

Moreno B, Bolea R, Martín-Burriel I, Sanz-Rubio D, Romero A, Vázquez FJ, Badiola JJ. Valvular endocarditis due to Enterococcus casseliflavus in a 4-month-old female foal. J. Equine Vet. Sci 34: 1352–1356 (2014).

Pérez M, Muñoz JA, Biescas E, Salazar E, Bolea R, De Andrés D, Amorena B, Badiola JJ, Reina R, Luján LL. Control del Visna/Maedi en una explotación ovina de aptitud lechera altamente infectada mediante estrategias de segregación serológica. Tierras ovino 9: 16-18 (2014).

Marin JM, Artal J, Martin T, Carrizo SJ, Andrés M, Martín-Burriel I, Bolea R, Sanz A, Varona L, Godino J, Gallego B, García-Erce JA, Villar I, Gil V, Forner M, Cubero JP, Ros L. Epigenetics modifications and subclinical atherosclerosis in obstructive sleep apnea: The EPIOSA study. BMC Pulm Med. 14: 114. (2014).

Aguilo N, Alvarez-Arguedas S, Uranga S, Marinova D, Monzón M, Badiola J, Martin C. Pulmonary but not subcutaneous vaccination confers protection to TB susceptible mice by an IL17-dependent mechanism. J Infect Dis 22 (2015).

Mediano DR, Sanz-Rubio D, Bolea R, Marín B, Vásquez FJ, Remacha AR, López-Pérez Ó, Fernández-Borges N, Castilla J, Zaragoza P, Badiola JJ, Rodellar C, Martín-Burriel I. Characterization of Mesenchymal Stem Cells in sheep naturally infected with scrapie. J Gen Virol 2 (2015).

Minguijón E, Reina R, Pérez M, Polledo L, Villoria M, Ramírez H, Leginagoikoa I, Badiola JJ, García-Marín JF, de Andrés D, Luján L, Amorena B, Juste RA. Small ruminant lentivirus infections and diseases. Vet Microbiol 28 (2015).

Sarasa R, Junquera C, Toledano A, Badiola JJ, Monzón M. Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol. Histochem Cell Biol 144: 77-85 (2015).

Serrano-Pérez P, Almería S, Tutusaus J, Jado I, Anda P, Monleón E, Badiola J, Garcia-Ispierto I, López-Gatius F. Coxiella burnetii total immunoglobulin G, phase I and phase II immunoglobulin G antibodies, and bacterial shedding in young dams in persistently infected dairy herds. J Vet Diag Invest 27:167-176 (2015).

Acín C. Scrapie: a particularly persistent pathogen. Vet Rec, 24:97-98 (2015).

Moreno B, Bolea R, Morales M, Martín-Burriel I, González C, Badiola JJ.Isolation and phylogenetic characterization of Streptococcus halichoeri from a European badger (Meles meles) with pyogranulomatous pleuropneumonia. J Comp Pathol 159:269-273 (2015).

Sarasa R, Junquera C, Toledano A, Badiola JJ, Monzón M. Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol. Histochem Cell Biol 144:77-85 (2015).

Hedman C, Bolea R, Marín B, Cobrière F, Filali H, Vazquez F, Pitarch J L, Vargas A, Acín C, Moreno B, Pumarola M, Andreoletti O, Badiola JJ. Transmission of sheep-bovine spongiform encephalopathy to pigs. Vet Res (Aceptado para su publicación) (2015).

Duque Velásquez C, Kim C, Herbst A, Daude N, Garza MC, Wille H, Aiken J, McKenzie D. Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains. J Virol 89(24):12362-73 (2015).

Kang SG, Kim C, Cortez LM, Carmen MC, Yang J, Wille H, Sim VL, Westaway D, McKenzie D, Aiken J. Toll-Like Receptor-Mediated Immune Response Inhibits Prion Propagation. GLIA. 64(6):937-51 (2016).

Fang C, Imberdis T, Garza MC, Wille H, Harris DA. A Neuronal Culture System to Detect Prion Synaptotoxicity. PLoS Pathogens. 12(5):e1005623 (2016)

Breid S, Bernis ME, Babila JT, Garza MC, Wille H, Tamgüney G. Neuroinvasion of alfa-synuclein prionoids after intraperitoneal and intraglossal inoculation. Journal of Virology. 90(20):9182-93 (2016).