Publicaciones recientes

López-Pérez Ó, Toivonen JM, Otero A, Solanas L, Zaragoza P, Badiola JJ, Osta R, Bolea R, Martín-Burriel I.Impairment of autophagy in scrapie-infected transgenic mice at the clinical stage. Lab Invest. 2020 Jan;100(1):52-63. doi: 10.1038/s41374-019-0312-z

Huor A, Espinosa JC, Vidal E, Cassard H, Douet JY, Lugan S, Aron N, Marín-Moreno A, Lorenzo P, Aguilar-Calvo P, Badiola J, Bolea R, Pumarola M, Benestad SL, Orge L, Thackray AM, Bujdoso R, Torres JM, Andreoletti O.  Proc Natl Acad Sci U S A. 2019 Dec 16. pii: 201915737. doi: 10.1073/pnas.1915737116

Garcés M, Guijarro MI, Vargas A, Badiola JJ, Monzón M. Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients. Mech Ageing Dev. 184:111176. (2019). doi: 10.1016/j.mad.2019.111176

Langeveld JPM, Pirisinu L, Jacobs JG, Mazza M, Lantier F, Simon S, Andréoletti O, Acin C, Esposito E, Fast C, Groschup M, Goldmann W, Spiropoulos J, Sklaviadis T, Lantier F, Ekateriniadou L, Papasavva-Stylianou P van Keulen LJM, Acutis PL, Agrimi U, Bossers A, Nonno R. 2019. Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods. Vet Res. 2019 Nov 25; 50(1):97. (doi:10.1186/s13567-019-0718-z)

Moreno B, Bolea R, Martín-Burriel I, Aceña MC, Morales M, Trujillo P, Badiola JJ. Pathology in Practice. J Am Vet Med Assoc. 255(6):669-672. (2019). doi:10.2460/javma.255.6.669

Rosell JM,  De la Fuente LF, Parra F, Dalton KP,  Badiola Sáiz JI, Pérez de Rozas A,  Badiola Díez JJ, Fernández de Luco D, Casal J, Majó N, Casas J, Garriga R, Fernández M. Myxomatosis and rabbit haemorrhagic disease: A 30-Year study of the occurrence on commercial farms in Spain. Animals (Basel). 9(10): 780.( 2019 Oct). doi: 10.3390/ani9100780

Moreno B, Bolea R, Andrés-Lasheras S, Sevilla E, Samper S, Morales M, Vargas A, Chirino-Trejo M, Badiola JJ. Antimicrobial susceptibilities and phylogenetic analyses of Enterococcus hirae Isolated from broilers with valvular endocarditis. Avian Dis. 63(2):318-324. (2019) doi: 10.1637/11986-102418-Reg.1

López-Pérez Ó, Bolea R, Marín B, Badiola JJ, Martín-Burriel I. Autophagy impairment in highly prion-affected brain areas of sheep experimentally infected with atypical scrapie. Vet Microbiol.233:78-84. (2019) doi: 10.1016/j.vetmic.2019.04.026

Otero A, Hedman C, Fernández-Borges N, Eraña H, Marín B, Monzón M, Sánchez-Martín MA, Nonno R, Badiola JJ, Bolea R, Castilla J.A Single amino acid substitution, found in mammals with low susceptibility to prion diseases, delays propagation of two prion strains in highly susceptible transgenic mouse models. Mol Neurobiol. 56(9):6501-6511. (2019). doi: 10.1007/s12035-019-1535-0

López-Pérez Ó, Otero A, Filali H, Sanz-Rubio D, Toivonen JM, Zaragoza P, Badiola JJ, Bolea R, Martín-Burriel I. Dysregulation of autophagy in the central nervous system of sheep naturally infected with classical scrapie. Sci Rep.9(1):1911. (2019). doi: 10.1038/s41598-019-38500-2

Otero A, Duque Velásquez C, Johnson C, Herbst A, Bolea R, Badiola JJ, Aiken J, McKenzie D. Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer. BMC Vet Res. 15(1):50.(2019). doi: 10.1186/s12917-019-1794-z

Pirisinu L, Andreoletti O, Lantier 1, Acutis PL, Acin C, Goldmann W, Sklaviadis T,Ekateriniadou L, Fast C, Papasavva – Stylianou P, Simon S, Spiropoulos J, Agrimi U,Jacobs JG, Bossers A, van Keulen LM, Mazza M, Nonno R,Langeveld JPM. TSEs in European goats discriminated by Western blotting into five types based on five robust molecular parameters. Prion, 13:sup1, 1-141, doi: 10.1080/19336896.2019.1615197

Nonno R, Marín-Moreno A, Espinosa JC, Fast C, Van Keulen L, Spiropoulos J, Lantier F, Andreoletti O, Pirisinu L, Di Bari MA, Aguilar-Calvo P, Sklaviadis T, Papasavva Stylianou P, Acutis PL, Acin C, Bossers A, Jacobs JG, Vaccari G, D’Agostino C,Chiappini B, Lantier F, Groschup M, Agrimi U, Torres JM, Langeveld JPM. Rodent models allow BSE discrimination of goat prions and reveal geographical differences in the biological properties of scrapie. Prion,13:sup1, 1-141. doi:10.1080/19336896.2019.1615197

Llorens F, Barrio T, Correia Â, Villar-Piqué A, Thüne K, Lange P, Badiola JJ, Schmitz M, Lachmann I, Bolea R, Zerr I. Cerebrospinal fluid prion disease biomarkers in pre-clinical and clinical naturally occurrings. Mol Neurobiol 55, 8586-8591 (2018). doi: 10.1007/s12035-018-1014-z

Hedman C, Otero A, Douet JY, Lacroux C, Lugan S, Filali H, Corbière F, Aron, N, Badiola JJ, Andréoletti O, Bolea R. Detection of PrPres in peripheral tissue in pigs with clinical disease induced by intracerebral challenge with sheep-passaged bovine spongiform encephalopathy agent. PLoS One 5, 13-27. e0199914 (2018). doi: 10.1371/journal.pone.0199914. eCollection 2018

Otero A, Bolea R, Hedman C, Fernández-Borges N, Marín B, López-Pérez O, Barrio T, Eraña H, Sánchez-Martín, MA, Monzón M, Badiola JJ, Castilla J. An amino acid substitution found in animals with low susceptibility to prion diseases confers a protective dominant-negative effect in prion-infected transgenic mice. Mol Neurobiol 55,6182-6192 (2018). doi: 10.1007/s12035-017-0832-8

Monzón M, Hernández RS, Garcés M, Sarasa R, Badiola JJ. Glial alterations in human prion diseases: A correlative study of astroglia, reactive microglia, protein deposition, and neuropathological lesions. Medicine (Baltimore), 97(15):e0320. (2018) doi: 10.1097/MD.0000000000010320

Pitarch JL, Raksa HC, Arnal MC, Revilla M, Martínez D, Fernández de Luco D, Badiola JJ, Goldmann W, Acín C. Low sequence diversity of the prion protein gene (PRNP) in wild deer and goat species from Spain. Vet Res 49, 33-39. (2018). doi: 10.1186/s13567-018-0528-8

Silva CJ, Erickson-Beltran ML, Martín-Burriel I, Badiola JJ, Requena JR, Bolea R. Determining the relative susceptibility of four protein genotypes to atypical scrapie. Anal Chem 90, 1255-1262. (2018) . doi: 10.1021/acs.analchem.7b03985

Bolea R, Hedman C, López-Pérez Ó, Marín B, Vidal E, Pumarola M, Corbière F, Romero A, Moreno B, Martín-Burriel I, Andréoletti O, Badiola JJ. Experimental transmission to a calf of an isolate of Spanish classical scrapie. J Gen Virol 98, 2628-2634 (2017). doi: 10.1099/jgv.0.000906

Costa MC, Goumperis T, Andersson W, Badiola J, Ooms W, Pongolini S.,Saegerman C, M. Jurkovic , P. Tuominen , E. Tsigarida , J. Steinwider , C. Hölzl ,N. Mikushinska , A. Gross-Boskovic , P. Kanari , M. Christodoulidou , L. Babicka , H. Korsgaard , S. Pesonen , A.M. Fillet , F. Foures , M. Lohman , P. Luber , M. Szab_o ,J. Cseh , H.P.J.M. Noteborn , K. Færden , Å. Fulke , T. Trnovec , N.G. Ilbäck ,T. Andersson , T. Donohoe , C. Merten , T. Robinson.  Risk identification in food safety: Strategy and outcomes of the EFSA emerging risks exchange network (EREN), 2010-2014. Food Control 73:255-264 (2017)

Tachu BJ, Wüsten KA, Garza MC, Wille H, Tamgüney G. An easy method for bacterial expression and purification of wild-type and mutant superoxide dismutase 1 (SOD1). Protein Expr Purif. 134:63-71. (2017) doi: 10.1016/j.pep.2017.04.001

Garza MC, Eraña H, Castilla J, Acín C, Vargas A, Badiola JJ, Monleón E. Protein misfolding cyclic amplification corroborates the absence of PrPSc accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie. Vet Microbiol 203, 294-300. (2017). doi: 10.1016/j.vetmic.2017.03.034

Breid S, Bernis ME, Tachu JB, Garza MC, Wille H, Tamgüney G. Bioluminescence imaging of neuroinflammation in transgenic mice after peripheral inoculation of alpha-ynuclein fibrils. J Vis Exp. 122. (2017).  doi: 10.3791/55503

Moreno B, Martín-Burriel I, Bolea R, Morales M, Sanz-Rubio D, Marín B, Espada J, Badiola    JJ. Pathology in practice. Severe hemorrhagic and fibrinonecrotic pneumonia and disseminated hemorrhages in sheep JAVMA. 250(5):509-512. (2017)

Sanz Rubio D, López-Pérez Ó, de Andrés Pablo Á, Bolea R, Osta R, Badiola JJ, Zaragoza P, Martín-Burriel I, Toivonen JM. Increased circulating microRNAs miR-342-3p and miR-21-5p in natural sheep prion disease. J Gen Virol 98, 305-310 (2017).  doi: 10.1099/jgv.0.000685

Silva CJ, Erickson-Beltran ML, Hui C, Badiola JJ, Nicholson EM, Requena JR, Bolea R. Quantitating PrP polymorphisms present in prions from heterozygous scrapie-infected sheep. Anal Chem 89, 854-861. (Enero 2017). doi: 10.1021/acs.analchem.6b03822

Aguilo N, Alvarez-Arguedas S, Uranga S, Marinova D, Monzón M, Badiola J, Martin C. Pulmonary but not subcutaneous delivery of BCG vaccine confers protection to tuberculosis-susceptible mice by an Interleukin 17-dependent mechanism. J Infect Dis. 213(5):831-839. (2016). doi: 10.1093/infdis/jiv503

Aguiló N, Uranga S, Marinova D, Monzon M, Badiola J, Martin C.MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice. Tuberculosis 96:71-74. (2016). doi: 10.1016/

Hedman C, Bolea R, Marín B, Cobrière F, Filali H, Vazquez F, Pitarch J L, Vargas A, Acín C, Moreno B, Pumarola M, Andreoletti O, Badiola JJ. Transmission of sheep-bovine spongiform encephalopathy to pigs. Vet Res 47:14. (2016) doi: 10.1186/s13567-015-0295-8

Garcés M, Toledano A , Badiola JJ,  Monzón M. Morphological changes of  glia in prion and a prion-like disorder. HSOA J Alzheimers Neurodegener Dis. 2(1):5-8 (2016).

Breid S, Bernis ME, Babila JT, Garza MC, Wille H, Tamgüney G. Neuroinvasion of alfa-synuclein prionoids after intraperitoneal and intraglossal inoculation. J Virol 90, 9182-9193 (2016).

Fang C, Imberdis T, Garza MC, Wille H, Harris DA. A Neuronal culture system to detect prion synaptotoxicity. PLoS Pathogens. 12(5):e1005623 (2016).

Kang SG, Kim C, Cortez LM, Garza MC, Yang J, Wille H, Sim VL, Westaway D, McKenzie D, Aiken J. Toll-Like receptor-mediated immune response inhibits prion propagation. GLIA. 64(6):937-51 (2016).

Sarasa R, Junquera C, Toledano A, Badiola JJ, Monzón M. Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol. Histochem Cell Biol. 144:77-85 (2015). doi: 10.1007/s00418-015-1314-6

Duque Velásquez C, Kim C, Herbst A, Daude N, Garza MC, Wille H, Aiken J, McKenzie D. Deer prion proteins modulate the emergence and adaptation of chronic wasting disease strains. J Virol 89(24):12362-73 (2015).

Sarasa R, Junquera C, Toledano A, Badiola JJ, Monzón M. Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol. Histochem Cell Biol 144:77-85 (2015).

Acín C. Scrapie: a particularly persistent pathogen. Vet Rec, 24:97-98 (2015).

Moreno B, Bolea R, Morales M, Martín-Burriel I, González C, Badiola JJ.Isolation and phylogenetic characterization of Streptococcus halichoeri from a European badger (Meles meles) with pyogranulomatous pleuropneumonia. J Comp Pathol 159:269-273 (2015).

Serrano-Pérez P, Almería S, Tutusaus J, Jado I, Anda P, Monleón E, Badiola J, Garcia-Ispierto I, López-Gatius F. Coxiella burnetii total immunoglobulin G, phase I and phase II immunoglobulin G antibodies, and bacterial shedding in young dams in persistently infected dairy herds. J Vet Diag Invest 27:167-176 (2015).

Sarasa R, Junquera C, Toledano A, Badiola JJ, Monzón M. Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol. Histochem Cell Biol 144: 77-85 (2015).

Minguijón E, Reina R, Pérez M, Polledo L, Villoria M, Ramírez H, Leginagoikoa I, Badiola JJ, García-Marín JF, de Andrés D, Luján L, Amorena B, Juste RA. Small ruminant lentivirus infections and diseases. Vet Microbiol 181(1-2):75-89. (2015).                             doi: 10.1016/j.vetmic.2015.08.007.28

Mediano DR, Sanz-Rubio D, Bolea R, Marín B, Vásquez FJ, Remacha AR, López-Pérez Ó, Fernández-Borges N, Castilla J, Zaragoza P, Badiola JJ, Rodellar C, Martín-Burriel I. Characterization of Mesenchymal Stem Cells in sheep naturally infected with scrapie. J Gen Virol 96:3715–3726. doi 10.1099/jgv.0.000292

Pérez M, Biescas E, Reina R, Glaria I, Marín B, Marquina A, Salazar E, Alvarez N, de Andrés D, Fantova E, Badiola JJ, Amorena B, Luján L. Small ruminant lentivirus-induced arthritis: Clinicopathologic findings in sheep infected by a highly replicative SRLV B2 genotype. Vet Pathol 52 1:132-139 (2015).

Marin JM, Artal J, Martin T, Carrizo SJ, Andrés M, Martín-Burriel I, Bolea R, Sanz A, Varona L, Godino J, Gallego B, García-Erce JA, Villar I, Gil V, Forner M, Cubero JP, Ros L. Epigenetics modifications and subclinical atherosclerosis in obstructive sleep apnea: The EPIOSA study. BMC Pulm Med. 14: 114. (2014).

Pérez M, Muñoz JA, Biescas E, Salazar E, Bolea R, De Andrés D, Amorena B, Badiola JJ, Reina R, Luján LL. Control del Visna/Maedi en una explotación ovina de aptitud lechera altamente infectada mediante estrategias de segregación serológica. Tierras ovino 9: 16-18 (2014).

Moreno B, Bolea R, Martín-Burriel I, Sanz-Rubio D, Romero A, Vázquez FJ, Badiola JJ. Valvular endocarditis due to Enterococcus casseliflavus in a 4-month-old female foal. J. Equine Vet. Sci 34: 1352–1356 (2014).

Salazar E, Berriatua E, Pérez M, Marín B, Acín C, Martín-Burriel I, Reina R,  de Andrés D,  Amorena B, Badiola JJ, Luján L. Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers. Span J Agric Res 12: 676-682 (2014).

González L, Pitarch JL, Martin S, Thurston L, Simmons, C. Acín C, Jeffrey M. Influence of the PrnP genotype on the pathogenesis and neuropathological phenotype of sheep Scrapie after oral infection J Comp Pathol 150: 57-70 (2014).

González L, Pitarch JL, Martin S, Thurston L, Moore J, Acín C, Jeffrey M. Identical pathogenesis and neuropathological phenotype of Scrapie in Valine, Arginine, Glutamine/Valine, Arginine, Glutamine sheep infected experimentally by the oral and conjunctival routes. J Comp Pathol 150: 47-56 (2014).

Hernández RS, Sarasa R, Toledano A, Badiola JJ, Monzón M. Morphological approach to assess the involvement of astrocytes in prion propagation. Cell Tissue Res. Tissue Res 358: 57-63  (2014).

Solans L, Uranga S, Aguilo N, Arnal C, Gomez AB, Monzon M, Badiola J, Gicquel B, Martin C. Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice. Vaccine 32:5192-5197(2014).

Garza MC, Monzon M, Marin B, Badiola JJ, Monleón E. Distribution of peripheral PrPsc in sheep with naturally acquired Scrapie. PLoS One. 14:9 (5):e97768.(2014). doi: 10.1371/journal.pone.0097768

Tutusaus J, López-Gatius F, Serrano B, Monleón E, Badiola JJ, Garcia-Ispierto I.Serological and shedding patterns after Coxiella burnetii vaccination in the third gestation trimester in dairy cows. Acta Vet Hung. 62:145-54 (2014).

Filali H, Martín-Burriel I, Harders F, Varona L, Hedman C, Mediano DR, Monzón M, Bossers A, Badiola JJ, Bolea R. Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie. BMC Genomics 15:59. (2014). doi: 10.1186/1471-2164-15-59.

Sarasa R, Becher D, Badiola JJ, Monzón M. A comparative study of modified confirmatory techniques and additional immuno-based methods for non-conclusive autolytic Bovine spongiform encephalopathy cases. BMC Vet Res. 18: 212 (2013).

Pérez M, Muñoz JA, Biescas E, Salazar E, Bolea R, de Andrés D, Amorena B, Badiola JJ, Reina R, Luján L. Successful Visna/maedi control in a highly infected ovine dairy flock using serologic segregation and management strategies. Prev Vet Med 112: 423-427 (2013).

Aguilo JI, Alonso H, Uranga S, Marinova D, Arbués A, de Martino A, Anel A, Monzon M, Badiola J, Pardo J, Brosch R, Martin C. ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis. Cell Microbiol 15(12):1994–2005 (2013). doi: 10.1111/cmi.12169

Acín C, Martín-Burriel I, Monleón E, Lyahyai J, Pitarch JL, Serrano C, Monzón  M, Zaragoza P, Badiola JJ. Prion protein gene variability in spanish goats. Inference through susceptibility to classical scrapie strains and pathogenic distribution of peripheral PrP(sc.). PLoS One. 8(4):e61118. (2013).

Filali H, Vidal E, Bolea R, Márquez M, Marco P, Vargas A, Pumarola M, Martin-Burriel I, Badiola JJ. Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep. Vet Res 44:14 (2013).

Minguijón E, González L, De Las Heras M, Gómez N, García-Goti M, Juste RA, Moreno B. Pathological and aetiological studies in sheep exhibiting extra-thoracic metástasis of ovine pulmonary adenocarcinoma (Jaagsiekte). J Com Path. 148(2-3):139–147 (2013).

Garcia-Ispierto I, López-Helguera I, Tutusaus J, Serrano B, Monleón E, Badiola J, López-Gatius F. Coxiella burnetii shedding during the peripartum period and subsequent fertility in dairy cattle. Reprod Domest Anim 48(3):441-446. (2013).

Aporta A, Arbues A, Aguilo JI, Monzon M, Badiola JJ, de Martino A, Ferrer N, Marinova D, Anel A, Martin C, Pardo J. Attenuated Mycobacterium tuberculosis SO2 vaccine candidate is unable to induce cell death. PLoS One. 7(9): e45213. (2012).

Lyahyai J, Mediano DR, Ranera B, Sanz A, Remacha AR, Bolea R, Zaragoza P, Rodellar C, Martín-Burriel I. Isolation and characterization of ovine mesenchymal stem cells derived from peripheral blood. BMC Vet Res. 8(1):169. (2012).

Larruskain A, Minguijón E, García-Etxebarria K, Arostegui I, Moreno B, Juste RA, Jugo BM. Amino acid signatures in the Ovar-DRB1 peptide-binding pockets are associated with Ovine Pulmonary Adenocarcinoma susceptibility/resistence. Biochem Bioph Res Co 428:463-468 (2012).

Hedman C, Lyahyai J, Filali H, Marín B, Serrano C, Monleón E, Moreno B, Zaragoza P, Badiola JJ, Martín-Burriel I, Bolea R. Differential gene expression and apoptosis markers in presymptomatic scrapie affected sheep. Vet Microbiol. 159:23-32. (2012).

Moreno B, Collantes-Fernández E, Villa A, Navarro A, Regidor-Cerrillo J, Ortega-Mora LM. Ocurrence of Neospora caninum and Toxoplasma gondii infections in ovine and caprine abortions. Vet Parasitol. 187:312-318 (2012).

Sarasa R, Martínez A, Monleón E, Bolea R, Vargas A, Badiola JJ, Monzón M. Involvement of astrocytes in transmissible spongiform encephalopathies: a confocal microscopy study. Cell Tissue Res 350(1):127-134 (2012).

Monzón M, Acín C, Bolea R, Monleón E, Vargas MA, Moreno B, Marín B, Hernández R, Pitarch JL, Hedman C, Jirón W, Filali H, Sarasa R, Garza MC, Badiola JJ. Las enfermedades priónicas, un antes y un después para la seguridad de los alimentos. Aplicaciones de la biotecnología en la ciencia veterinaria. Ed. Instituto Tomás Pascual y Sanz. 135-177.(2012).

Toledano A, Álvarez MI, Monleón E, Toledano-Díaz A, Badiola JJ, Monzón M. Changes induced by natural scrapie in the calretinin-immunopositive cells and fibres of the sheep cerebellar cortex. Cerebellum. 11(2):593-604 (2012).

Filali H, Martín-Burriel I, Harders F, Varona L, Serrano C, Acín C, Badiola JJ, Bossers A, Bolea R. Medulla oblongata transcriptome changes during presymptomatic natural scrapie and their association with prion-related lesions. BMC Genomics. 13, 399. (2012).

Badiola Díez JJ, Acín C, Bolea R, Moreno B, Marín B, Monleón E, Monzón M, Vargas A. Erradicación de la Peste bovina. Erradicación y Control de las Enfermedades Producidas por Virus. Ed. Fundación Ramón Areces. 21 – 45. ISBN M-16405-2012.

Larruskain A, Minguijón E, Arostegui I, Moreno B, Juste RA, Jugo BM. Microsatellites in immune-relevant regions and their associations with Maedi-Visna and ovine pulmonary adenocarcinoma viral diseases. Vet Immunol Immunopathol 145:438-446. (2012).

Álvarez-Rodríguez J, Monleón E, Sanz A, Badiola JJ, Joy M. Rumen fermentation and histology in light lambs as affected by forage supply and lactation length. Res Vet Sci. 92: 247-253 (2012).

Garza MC, Fernández-Borges N, Bolea R, Badiola JJ, Castilla J, Monleón E. In utero vertical transmission of scrapie in natural infected ewes. PLoS One. 6(12): e27525. (2011).

Filali H, Martín-Burriel I, Harders F, Varona L, Lyahyai J, Zaragoza P, Pumarola M, Badiola JJ, Bossers A, Bolea R. Gene expression profiling and association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals. PLoS One. 6(5):e19909. (2011).

Galindo-Cardiel I, Fernández-Jiménez M, Luján L, Buesa J, Espada J, Fantova E, Blanco J, Segalés J, Badiola JJ. Novel group A rotavirus G8 P[1] as primary cause of an ovine diarrheic syndrome outbreak in weaned lambs. Vet Microbiol 149: 467-471 (2011).

Serrano C, Bolea R, Lyahyai J, Filali Hm, Varona L, Marcos-Carcavilla A, Acín C, Calvo JH, Serrano M, Badiola JJ, Zaragoza P, Martín-Burriel I. Changes in HSP gene and protein expression in natural scrapie with brain damage. Vet Res 42:13-24 (2011).

Monleón E, Garza M, Sarasa R, Alvarez-Rodriguez J, Bolea R, Monzón M, Vargas MA, Badiola JJ, Acín C. An assessment of the efficiency of PrPsc detection in rectal mucosa and third-eyelid biopsies from animals infected with scrapie. Vet Microbiol 147:237-243 (2011).

González L, Sisó S, Monleón E, Casalone C, Van Keulen LJ, Balkema-Buschmann A, Ortiz-Peláez A, Iulini B, Langeveld JP, Hoffmann C, Badiola JJ, Jeffrey M, Acín C. Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe. J Gen Virol 91:2630-2641 (2010).

Salazar E, Monleón E, Bolea R, Acín C, Pérez M, Alvarez N, Leginagoikoa I, Juste R, Minguijón E, Reina R, Glaria I, Berriatua E, De Andrés D, Badiola JJ, Amorena B, Luján L. Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep. Vet Res 41: 58-67 (2010).

Leginagoikoa I, Minguijón E, Juste R, Barandika J, Amorena B, De Andrés D, Badiola JJ, Luján L, Berriatua E. Effects of housing on the incidence of visna/maedi virus infection in sheep flocks. Res Vet Sci 88: 415-21 (2010).

Bolea R, Vidal E, Marín B, Márquez M, Vargas A, Pumarola M, Badiola JJ. Rapid chromatographic immunoassay study of brain PrPsc distribution in classical scrapie. J Vet Diagn Invest 22: 82-85. (2010).

Bolea R, Hortells P, Martín-Burriel I, Vargas A, Ryffel B, Monzón M, Badiola JJ. Consequences of dietary manganese and copper imbalance on neuronal apoptosis in a murine model of scrapie. Neuropath Appl Neuro 36: 300-311 (2010).

Badiola JJ y  Pumarola M. Encefalopatias espongiformes transmisibles. 146 págs.   ISBN: 978-84-9905-073-7 Editorial: Ediciones Mayo S.A. Barcelona. España. (2010).

Lyahyai J, Serrano C, Ranera B, Badiola JJ, Zaragoza P, Martin-Burriel I. Effect of scrapie on the stability of housekeeping genes. Anim Biotechnol.;21 : 1-13. (2010).

Hortells P, Monleón E, Acín C, Vargas A, Vasseur V, Salomon A, Ryffel B, Cesbron I, Badiola JJ, Monzón M. The effect of metal imbalances on scrapie neurodegeneration. Zoonoses and Public Health 57:358-66 (2010).

Pérez M, Biescas E, De Andrés X, Leginagoikoa I, Salazar E, Berriatua E, Reina R, Bolea R, De Andrés D, Juste RA, Cancer J, Gracia J, Amorena B, Badiola J, Luján L. Visna/maedi virus serology in sheep: Survey, risk factors and implementation of a successful control programme in Aragón (Spain). Vet J. 186(2):221-225. (2010).